Rivercell

Building the AI Virtual Cell to decipher biology and disease

The cell is the fundamental unit of life. Rivercell is building the platform to understand how cells change in disease and predict how they respond to treatment.

The problem

Cell response to treatment remains largely unpredictable

Treatment response depends on cellular state, genetic background, environment and previous exposures. Cells can also adapt and develop resistance.

We need to predict which interventions, alone or in sequence, restore function or eliminate diseased cells while limiting harm to healthy tissue.

The data gap

Four recurring gaps in today's cellular data

Observational

Cellular states are recorded without testing responses to interventions.

Monomodal

A single readout leaves molecular and cellular responses unlinked.

Static

A single timepoint leaves each cell’s response over time unobserved.

Context-poor

Too few cell types, genetic backgrounds and environments limit prediction in new contexts.

What we build

The platform that generates the right data at scale to unlock the AI Virtual Cell

We are building a proprietary, programmable platform and a world model of the cell as one lab-in-the-loop. The model will choose experiments; the platform will run them at scale. Each result will improve predictions and guide the next experiment.

Biological inputs

Rivercell platform

World model of the cell

Read the manifesto →
observational

Perturbational

Interventions tested against controls, alone, in combinations and in sequence.

monomodal

Multimodal

Live-cell imaging linked to endpoint gene expression in the same cells.

static

Longitudinal

The same cells tracked over time to distinguish transient responses, adaptation and delayed effects.

context-poor

Context-diverse

The same interventions tested across cell types, genetic backgrounds and environments.